{"product_id":"pt-141","title":"PT-141","description":"\u003ch2 data-section-id=\"14qi2yg\" data-start=\"0\" data-end=\"42\" class=\"PDq2pG_selectionAnchorContainer\"\u003ePT-141 – Research Applications Overview\u003cspan aria-hidden=\"true\" class=\"PDq2pG_selectionAnchor\"\u003e\u003c\/span\u003e\n\u003c\/h2\u003e\n\u003cp data-start=\"44\" data-end=\"552\"\u003ePT-141, also known as \u003cstrong data-start=\"66\" data-end=\"83\"\u003ebremelanotide\u003c\/strong\u003e, is a synthetic cyclic peptide derived from the melanocortin peptide pathway. It is primarily studied as a melanocortin-receptor agonist, with activity involving the \u003cstrong data-start=\"250\" data-end=\"277\"\u003eMC3R and MC4R receptors\u003c\/strong\u003e located within the central nervous system. Unlike compounds that act mainly through peripheral blood-flow pathways, PT-141 research focuses on neurological signalling associated with sexual motivation, arousal and behavioural responses. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 data-section-id=\"6bvmjm\" data-start=\"554\" data-end=\"582\"\u003eKey Research Applications\u003c\/h2\u003e\n\u003ch3 data-section-id=\"1e4kd07\" data-start=\"584\" data-end=\"622\"\u003e● Melanocortin-Receptor Signalling\u003c\/h3\u003e\n\u003cp data-start=\"624\" data-end=\"701\"\u003eStudied in experimental models examining activation of melanocortin receptors\u003c\/p\u003e\n\u003cp data-start=\"703\" data-end=\"786\"\u003eUsed to investigate the roles of MC3R and MC4R in central nervous-system signalling\u003c\/p\u003e\n\u003cp data-start=\"788\" data-end=\"886\"\u003eExplored to understand how melanocortin pathways influence behavioural and physiological responses\u003c\/p\u003e\n\u003cp data-start=\"888\" data-end=\"980\"\u003eApplied in receptor-binding and activation studies comparing different melanocortin agonists\u003c\/p\u003e\n\u003ch3 data-section-id=\"18e1b1q\" data-start=\"982\" data-end=\"1026\"\u003e● Sexual Motivation and Arousal Research\u003c\/h3\u003e\n\u003cp data-start=\"1028\" data-end=\"1105\"\u003eStudied in models investigating centrally regulated sexual desire and arousal\u003c\/p\u003e\n\u003cp data-start=\"1107\" data-end=\"1178\"\u003eUsed to examine neurological pathways associated with sexual motivation\u003c\/p\u003e\n\u003cp data-start=\"1180\" data-end=\"1264\"\u003eExplored for its effects on subjective and physiological measures of sexual response\u003c\/p\u003e\n\u003cp data-start=\"1266\" data-end=\"1352\"\u003eInvestigated in both male and female research models to compare sex-specific responses\u003c\/p\u003e\n\u003cp data-start=\"1354\" data-end=\"1521\"\u003eResearch suggests that MC4R activation may influence hypothalamic pathways and dopamine signalling involved in sexual motivation. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 data-section-id=\"xzdsnu\" data-start=\"1523\" data-end=\"1569\"\u003e● Neuroendocrine and Hypothalamic Pathways\u003c\/h3\u003e\n\u003cp data-start=\"1571\" data-end=\"1675\"\u003eApplied in studies analysing communication between the brain, endocrine system and behavioural responses\u003c\/p\u003e\n\u003cp data-start=\"1677\" data-end=\"1744\"\u003eUsed to investigate neuronal activation within hypothalamic regions\u003c\/p\u003e\n\u003cp data-start=\"1746\" data-end=\"1838\"\u003eExplored for its interaction with neurotransmitter systems involved in motivation and reward\u003c\/p\u003e\n\u003cp data-start=\"1840\" data-end=\"1941\"\u003eStudied to evaluate how melanocortin signalling influences centrally mediated physiological processes\u003c\/p\u003e\n\u003ch3 data-section-id=\"109zzk8\" data-start=\"1943\" data-end=\"1976\"\u003e● Male Sexual-Response Models\u003c\/h3\u003e\n\u003cp data-start=\"1978\" data-end=\"2060\"\u003eInvestigated in preclinical and early clinical models examining erectile responses\u003c\/p\u003e\n\u003cp data-start=\"2062\" data-end=\"2153\"\u003eUsed to study centrally mediated mechanisms that differ from nitric-oxide and PDE5 pathways\u003c\/p\u003e\n\u003cp data-start=\"2155\" data-end=\"2241\"\u003eApplied in research comparing melanocortin agonists with peripheral vascular compounds\u003c\/p\u003e\n\u003cp data-start=\"2243\" data-end=\"2403\"\u003eEarly studies evaluated intranasal PT-141 in healthy male participants and men with mild-to-moderate erectile dysfunction. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 data-section-id=\"1n6s5e7\" data-start=\"2405\" data-end=\"2442\"\u003e● Female Sexual-Function Research\u003c\/h3\u003e\n\u003cp data-start=\"2444\" data-end=\"2538\"\u003eStudied in clinical research involving acquired, generalised hypoactive sexual desire disorder\u003c\/p\u003e\n\u003cp data-start=\"2540\" data-end=\"2603\"\u003eUsed to assess changes in sexual desire and associated distress\u003c\/p\u003e\n\u003cp data-start=\"2605\" data-end=\"2709\"\u003eInvestigated through controlled trials measuring patient-reported behavioural and psychological outcomes\u003c\/p\u003e\n\u003cp data-start=\"2711\" data-end=\"3015\"\u003eBremelanotide is also the active ingredient in the prescription medicine Vyleesi, which is FDA-approved for certain premenopausal women with acquired, generalised HSDD. It is not approved to enhance sexual performance or to treat HSDD in men or postmenopausal women. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch2 data-section-id=\"lrt0bb\" data-start=\"3017\" data-end=\"3062\"\u003eHow PT-141 Is Studied in Research Settings\u003c\/h2\u003e\n\u003ch3 data-section-id=\"apdmjd\" data-start=\"3064\" data-end=\"3095\"\u003e● In Vitro Receptor Studies\u003c\/h3\u003e\n\u003cp data-start=\"3097\" data-end=\"3170\"\u003eConducted using melanocortin-receptor-expressing cell systems to analyse:\u003c\/p\u003e\n\u003cp data-start=\"3172\" data-end=\"3197\"\u003eReceptor-binding affinity\u003c\/p\u003e\n\u003cp data-start=\"3199\" data-end=\"3223\"\u003eMC3R and MC4R activation\u003c\/p\u003e\n\u003cp data-start=\"3225\" data-end=\"3259\"\u003eIntracellular signalling responses\u003c\/p\u003e\n\u003cp data-start=\"3261\" data-end=\"3293\"\u003eDose-dependent receptor activity\u003c\/p\u003e\n\u003ch3 data-section-id=\"thapek\" data-start=\"3295\" data-end=\"3327\"\u003e● In Vivo Preclinical Models\u003c\/h3\u003e\n\u003cp data-start=\"3329\" data-end=\"3374\"\u003eUsed in controlled animal studies to examine:\u003c\/p\u003e\n\u003cp data-start=\"3376\" data-end=\"3408\"\u003eSexual and behavioural responses\u003c\/p\u003e\n\u003cp data-start=\"3410\" data-end=\"3442\"\u003eHypothalamic neuronal activation\u003c\/p\u003e\n\u003cp data-start=\"3444\" data-end=\"3469\"\u003eNeuroendocrine signalling\u003c\/p\u003e\n\u003cp data-start=\"3471\" data-end=\"3523\"\u003eChanges in centrally mediated physiological activity\u003c\/p\u003e\n\u003ch3 data-section-id=\"n5dpen\" data-start=\"3525\" data-end=\"3548\"\u003e● Clinical Research\u003c\/h3\u003e\n\u003cp data-start=\"3550\" data-end=\"3599\"\u003eEvaluated in controlled human trials focusing on:\u003c\/p\u003e\n\u003cp data-start=\"3601\" data-end=\"3623\"\u003eSexual-desire outcomes\u003c\/p\u003e\n\u003cp data-start=\"3625\" data-end=\"3649\"\u003eSexual-arousal responses\u003c\/p\u003e\n\u003cp data-start=\"3651\" data-end=\"3684\"\u003eTreatment-related distress scores\u003c\/p\u003e\n\u003cp data-start=\"3686\" data-end=\"3721\"\u003ePharmacokinetic and safety profiles\u003c\/p\u003e\n\u003cp data-start=\"3723\" data-end=\"3762\"\u003eBlood-pressure and heart-rate responses\u003c\/p\u003e\n\u003cp data-start=\"3764\" data-end=\"3933\"\u003ePhase 3 studies evaluated subcutaneous bremelanotide in premenopausal women with HSDD using randomised, placebo-controlled designs. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 data-section-id=\"191987m\" data-start=\"3935\" data-end=\"3976\"\u003e● Molecular and Neurological Analysis\u003c\/h3\u003e\n\u003cp data-start=\"3978\" data-end=\"4010\"\u003eResearch techniques may include:\u003c\/p\u003e\n\u003cp data-start=\"4012\" data-end=\"4051\"\u003eMelanocortin-receptor activation assays\u003c\/p\u003e\n\u003cp data-start=\"4053\" data-end=\"4083\"\u003eNeuronal activity measurements\u003c\/p\u003e\n\u003cp data-start=\"4085\" data-end=\"4118\"\u003eNeurotransmitter pathway analysis\u003c\/p\u003e\n\u003cp data-start=\"4120\" data-end=\"4158\"\u003eHormonal and cardiovascular monitoring\u003c\/p\u003e\n\u003cp data-start=\"4160\" data-end=\"4191\"\u003eBehavioural-response assessment\u003c\/p\u003e\n\u003ch2 data-section-id=\"ob2l5l\" data-start=\"4193\" data-end=\"4219\"\u003eResearch Considerations\u003c\/h2\u003e\n\u003cp data-start=\"4221\" data-end=\"4342\"\u003ePT-141 acts mainly through \u003cstrong data-start=\"4248\" data-end=\"4281\"\u003ecentral melanocortin pathways\u003c\/strong\u003e, rather than functioning solely as a peripheral vasodilator.\u003c\/p\u003e\n\u003cp data-start=\"4344\" data-end=\"4490\"\u003eIts precise mechanism in modifying sexual desire is not fully established, although MC4R-mediated neurological signalling is considered important.\u003c\/p\u003e\n\u003cp data-start=\"4492\" data-end=\"4719\"\u003eResearch should account for possible transient increases in blood pressure, reductions in heart rate, nausea and focal hyperpigmentation reported with clinically administered bremelanotide. \u003cspan class=\"\" data-state=\"closed\"\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cp data-start=\"4721\" data-end=\"4881\" data-is-last-node=\"\" data-is-only-node=\"\"\u003ePT-141 and bremelanotide should not be presented as universally approved for libido enhancement, erectile dysfunction or general sexual-performance improvement.\u003c\/p\u003e","brand":"Australian Peptide Research Institute","offers":[{"title":"Default Title","offer_id":53848797708399,"sku":null,"price":49.99,"currency_code":"AUD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0719\/4938\/5839\/files\/australia_46.png?v=1784471603","url":"https:\/\/apripeptides.com\/products\/pt-141","provider":"Australian Peptide Research Institute","version":"1.0","type":"link"}